Union University opened a second campus in the Memphis suburb of Germantown, Tennessee in 1997 which is located on fourteen acres of property with a single, multi-purposed, two-story 39,000 square foot building. The campus contains academic support services (registrar, financial aid, business services, library), classrooms, nursing labs, and nursing simulation stations.

Union University Germantown provides the nontraditional, adult learner in the Memphis metropolitan area with high quality, undergraduate and graduate degrees as well as professional development opportunities. The Department of Continuing Studies offers degree completion courses leading to the Bachelor of Science in Organizational Leadership in one of four concentrations; Church Leadership, Organizational Leadership, Project Management, Health Management. The School of Education offers the Masters of Education, the Masters of Arts in Education, the Education Specialist, and Doctorate of Education degrees. The Masters of Business Administration Degree is offered by the McAfee School of Business Administration. The School of Nursing offers the Bachelor of Science in Nursing, the RN to BSN, the Masters of Science in Nursing, and the Doctorate of Nursing Practice degrees. All programming at Union University Germantown is taught within a Christian context consistent with the overall guiding principles of Union University.