The Sioux City Lewis & Clark Interpretive Center and the Betty Strong Encounter Center comprise an almost 20,000-square-foot, private, non-profit cultural complex, built and sustained by Missouri River Historical Development, Inc. (MRHD).

The Interpretive Center opened in 2002 to commemorate the Lewis & Clark Bicentennial. It expanded in late 2007 with the opening of the adjoining Betty Strong Encounter Center to fulfill a permanent mission of "commemorating a history of encounters" before, during and after the expedition.

Joined by the symbolic Crossroads, these two parts create a Missouri Riverfront home for exhibits, programs and activities that explore how we live together as diverse people; and how we care for our land, our great river and other natural resources. Admission and programs are free.