The Littleton Fire Department is a combination department consisting of a full-time Chief, 4 full-time firefighter/EMTs, a part-time administrative assistant, 8 on-call officers, 30 on-call firefighters and/or EMTs, and 10 reserve firefighters and/or EMTs. The department serves Littleton, Massachusetts, a suburban community of about 8900 residents approximately 25 miles west of Boston and located along Interstate 495. The community's composition is making a transition from agricultural to primarily residential and business. Communities adjacent to the west are much more rural while those to the east and north are considered truly suburban.

The Littleton Fire Department responded to 1244 emergency service calls in 2005. The department currently operates two engine companies, an engine/rescue company, a 110’ ladder company, a rescue company, two BLS-level ambulances (supplemental ALS-level medical care is provided by Emerson Hospital paramedics), a mini attack/interface engine company, a hazardous materials spill containment trailer, and various other support vehicles. The department also offers marine and cold water/ice rescue capabilities