Before Potomac Hospital opened, there was no civilian hospital between Fredericksburg and Alexandria. Residents of eastern Prince William County knew that building their own hospital would cut travel time for medical care by 30 to 45 minutes. In 1965 the Woodbridge Jaycees hired professional consultants to study the feasibility of building a hospital in the area. Architects were hired and at least five sites were surveyed to determine the hospital's location.
In June 1968, community leaders joined together to form the Potomac Hospital Corporation, and elected John Johnson, then head of Virginia Power, as president. In 1969 the first hospital membership drive began and soon there were 3,300 members ready and willing to support the hospital's fundraising efforts. When all was said and done, over $2 million was raised by the community to help build and open Potomac Hospital.