South Tampa was the tenth Smokehouse to open in the Sunshine State and is located just down the road from Raymond James Stadium, downtown, the bay, and the Florida Aquarium. It’s also located only a couple of miles from the University of Tampa. Visit us at 623 South MacDill Ave. Tampa FL 33609 for South Tampa's best BBQ. From their Signature Angus Brisket and Southern-Style Pulled Pork, Burnt Ends, Prime Rib and Smoked Chicken to the Smokehouse 2 x 2 or Pitmaster Combo, there is plenty of delicious barbeque at 4 Rivers South Tampa. 4 Rivers Smokehouse is a family-owned business specializing in slow-smoked barbecue, home-style sides, and fresh bakery items, in a family-friendly casual dining environment.