Harrington Discovery Institute at University Hospitals is an international drug discovery and development organization established to address unmet therapeutic need. It provides comprehensive support to leading scholars and entrepreneurs across academic centers in the US, UK, and Canada with a focus on medical breakthroughs that show great promise but otherwise would not advance to clinical trials. By concentrating philanthropic, scientific and business development resources during the early, high-risk stage of development and creating milestone-driven pathways toward commercialization, Harrington Discovery Institute de-risks therapeutic candidates in preparation for further investment.